What is Janeway Lesion? | Symptoms, Causes and Treatment

In simple terms, Janeway lesion is a collection of pus within the tissues of the body with marked localized death of living tissue and inflammatory filtrate not involving the epidermis. The Janeway Lesions are distal, flat, eccchymortic and painless. They got the name from Edward Janeway (1841-1911). Edward Janeway was a prominent American Physician and a pathologist. He is the person who initially described the lesions. After a brief research, this condition was named after him.

Is there any relationship between Osler’s Nodes and Janeway Lesions?

According to research, the two conditions are almost similar. The only noticeable difference is that the Osler’s Nodes are painful when touched with fingertip or especially when pressure is excreted in the affected area. Unlike Osler’s nodes, Janeway Lesions are not tender and they usually occur on the palms and at the base of the thumb and little fingers.

Causes of Janeway Lesions

There are several causes of Janeway Lesions as discussed below.

  • They are caused by infected and contaminated particles circulating in Blood and also depositions of bacteria which eventually forms a painless area of inflamed tissue filled with pus.
  • The other cause is bacteria that has originated from an infection of the lining of the heart.
  • They also may occur due to cutaneous immune-complex mediated by vasculitities. This is only present in about 25 percent of the patients with the inflammation of the lining of the heart and its nerves.
  • Janeway Lesions also occur in Endocarditis caused by Staphylococcus aureus.
  • There’s another claim that they are caused by septic emboli. They can as well be caused by the result from the depositing of immune complexes. The resulting responses leads to swelling, redness and pain that seems as a characteristic for these lesions.

Symptoms of Janeway Lesions

There are several symptoms of Janeway Lesions which includes;

  • A small area of bleeding under the nails. It is called splinter hemorrhages.
  • The other thing is that you are likely to observe red colored and painless skin spots on the flat, expanded concave part of the palms of the hands between the wrist, the bases of the finger and the soles.
  • The third symptom is that there are red colored painful nodes when touched in the pads of the fingers and toes. They usually look similar to Osler’s nodes.
  • The patient is likely to experience very high shortness of breath during hard activities or during exercise.
  • The other one is the swelling and the inflammation of the feet, the dorsal part of the abdomen and the legs.
  • You may also notice that the color of skin lesions may change from reddish to purplish.
  • You are likely to notice painless skin spots. In case of Osler’s nodes, these spots are painful.

Finally, you will notice irregular injured and diseased spot on the skin of hands and feet.

Janeway Lesions Treatment

The treatment of Janeway lesions relies entirely on the causative agent. If Janeway lesions are caused by an infection, then broad spectrum anti-biotic such as fluoroquinolones and aminoglycosides are administered. They are likely to eradicate the infection completely and eventually correct the condition.

There are several other treatment methods available such as Eucalyptus oil and neem oil. Eucalyptus oils has an anti-inflammatory effects that can really help treat this condition. Neem oil has the same properties that can help correct the situation. However, you must know that there are no scientific support for these claims. The other thing is that skin lesions tend to heal on their own if left untreated for some time. Though, it is better to take appropriate measures and correct the situation to avoid the discomfort associated with it.


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